Wales face second-row injury problems in their summer programs against South Africa and Australia.
Cardiff lock Teddy Williams joins Ospreys duo Adam Beard and Rhys Davies to miss the game through injury.
Williams underwent shoulder surgery, and Beard (ankle) and Davis (knee) will not return until next season.
Young uncapped Ospreys lock James Fender is yet to return to full training after suffering a serious arm injury in January.
Exeter duo Dafydd Jenkins and Christ Tshiunza will not be able to take part in the South African match as it takes place outside World Rugby’s international window, which rules out players from UK-based clubs unless a deal is reached, while Will Rowlands plays for Racing. In France, 92.
Dragons lock Ben Carter and Cardiff second-row Seb Davies are specialist options, while Scarlets flanker Taine Plumtree could fill the spot, while Ospreys back-row James Ratti has also featured as a lock.
Wales have been linked with the recall of Corey Hill, who has been sidelined in recent seasons due to playing club rugby in Japan.
Warren Gatland’s side face world champions South Africa at Twickenham on June 22 and then play three games in Australia in July.
Wales will play test matches against the Wallabies in Sydney and Melbourne on July 6 and July 13 respectively, before playing the final against the Queensland Reds on July 19.
