Scotland manager Gregor Townsend has made 13 changes to his line-up ahead of their final summer test against Uruguay in Montevideo.
The only players to survive last weekend’s win over Chile are Kyle Lowe and flyhalf Ben Healy, with Lowe moving from full-back to right winger in place of Harry Paterson.
Centre Hugh Jones, 30, was capped for the national team in his 50th cap, while Scotland’s joint-leading try scorer Duhan van der Merwe played on the wing opposite Lowe.
Centre Stafford McDowall and scrum-half George Horne form the back line, while Rory Sutherland, Ewan Ashman and Javan Sebastian form the new front row.
The second row features Alex Williamson alongside Scott Cummings, while the back row includes Luke Crosby, captain Rory Dodge and Matt Fagerson.
Paterson is the least experienced of the 15-man squad, having won just two caps for his country, while hooker Patrick Harrison could be handed his second Scotland cap as a substitute.