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semaglutide drug —including Ozempic and Wegovy—have been shown to reduce the risk of kidney failure and death in people with kidney disease and type 2 diabetes.
In a UNSW Sydney-led trial from June 2019 to May 2021, researchers found that giving small doses of semaglutide weekly reduced the likelihood of “major kidney disease” by 24%, according to a press release.
The study, funded by Novo Nordisk and published in The New England Journal of Medicine, included more than 3,500 participants. type 2 diabetes Chronic kidney disease in 28 countries.
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Participants received 1.0 mg of semaglutide per week, which is less than is typically prescribed. weight loss Or announced that you have diabetes.
The average follow-up period was 3.4 years.
Semaglutide drugs, including Ozempic and Wegovy, have been shown to reduce the risk of kidney failure and death in people with kidney disease and type 2 diabetes. (iStock)
“We used the same compound but at a lower dose. We did this intentionally because people with kidney disease tend to be more sensitive to the effects and side effects of the drug,” said Professor Vlado Perkovic, lead author of the study. UNSW Sydney is now available.
“It helps that the drug will be more widely available than it would be if there were current supply constraints.”
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The group taking semaglutide was also 18% less likely to experience the following symptoms: heart attack, stroke And other cardiovascular diseases were also discovered.
Why does semaglutide have these effects?
According to Dr. Brett Osborn, a Florida neurologist and longevity expert, patients with type 2 diabetes and chronic kidney disease are at very high risk for kidney failure, cardiovascular disease and death.
“A recent study published in the New England Journal of Medicine highlights the potential of semaglutide to mitigate these risks,” Osborn, who was not involved in the study, told Fox News Digital.
Dr. Brett Osborn, a Florida neurologist and longevity expert, noted that patients with type 2 diabetes and chronic kidney disease are at significant risk for kidney failure, cardiovascular events and death. (Dr. Brett Osborne)
Semaglutide works by improving blood sugar control, which is important in alleviating diabetic nephropathy (kidney disease), Osborn noted.
“It also reduces inflammation, especially within the lining of blood vessels,” he said.
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This reduces blood vessel damage and improves blood flow through the kidneys.
“Overall, semaglutide provides significant renal and cardiovascular protection in patients with type 2 diabetes and chronic kidney disease,” Dr. Osborne said.
“Basically, semaglutide improves vascular health through an indirect mechanism: the better the blood flow to organs such as the heart, brain or kidneys. you are more likely to live longer.”
One doctor noted that semaglutide works by improving blood sugar control, which is important in relieving diabetic nephropathy (kidney disease). (Getty Images)
Aside from the scope of diabetes, Osborn said he believes these drugs will have a major impact on human health, comparing them to the advent of antibiotics at the turn of the century.
Dr. Marc Siegel, Clinical Professor, School of Medicine NYU Langone Medical Center The Fox News medical contributor said this was a “very important” study.
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“These life-saving results are likely due to the metabolic effects of the drug, which help reduce inflammation, overcome insulin resistance, and improve insulin function and glucose metabolism at the cellular level,” Siegel told Fox News Digital.
“This study has wider implications for all patients with kidney failure.”
“Improved kidney function means improved heart function, and the pressure on the heart caused by poor kidney function is a major cause of: heart attack and death.”
“This study has broader implications for all patients with or at risk of kidney failure,” Siegel added.
Novo Nordisk, the Denmark-based company that manufactures Ozempic and Wegovy, announced positive primary results from the trial at the European Renal Association (ERA) meeting in Sweden last week. (LISELOTTE SABROE/Scanpix Denmark/AFP via Getty Images)
Novo Nordisk, the Denmark-based company that manufactures Ozempic and Wegovy, announced positive primary results from the trial at the European Renal Association (ERA) meeting in Sweden last week.
“FLOW is the first renal outcomes trial using a GLP-1 receptor agonist and has shown a statistically significant reduction in the risk of kidney disease progression, cardiovascular death, and all-cause mortality using 1 mg of semaglutide,” said Michael. Medical Director Radin said. Novo Nordisk’s Diabetes said in a statement to Fox News Digital.
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“This study highlights our drive to make a meaningful difference in the lives of people living with type 2 diabetes and CKD and to deliver innovations to address the current unmet medical needs in CKD, pending FDA approval. “
Wegovy is an injectable prescription weight loss medication that helps people who are obese. (Michael Siluk/UCG/Universal Images Group via Getty Images)
In order to use semaglutide as a treatment for kidney disease, it is necessary to overcome the supply shortage and conduct research on it. combine drugs The researchers used it in conjunction with other treatments, the release said.
Novo Nordisk also needs to get regulatory approval for the drug for use in patients with chronic kidney disease.
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“The idea is to put these results into clinical practice and have a drug that will be used by people who, if they take it, can live longer without dialysis or heart attacks or strokes,” Perkovic said.
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